Sermorelin vs. HGH Human Growth Hormone Therapy
Sermorelin vs. HGH Therapies.
Understanding the differences.
HGH Human Growth Hormone
HGH is produced by the pituitary gland to fuel growth and development in children. It also maintains some bodily functions, like tissue repair, muscle growth, brain function, energy, and metabolism, throughout life.
But will growth hormone boost performance or slow aging? And is it safe?
Human growth hormone: Up close and personal
Growth hormone (GH) is a small protein that is made by the pituitary gland and secreted into the bloodstream. GH production is controlled by a complex set of hormones produced in the hypothalamus of the brain and in the intestinal tract and pancreas.
The pituitary puts out GH in bursts; levels rise following exercise, trauma, and sleep. Under normal conditions, more GH is produced at night than during the day. This physiology is complex, but scientists who carefully measure overall GH production report that it rises during childhood, peaks during puberty, and declines from middle age onward.
GH acts on many tissues throughout the body. In children and adolescents, it stimulates the growth of bone and cartilage. In people of all ages, GH boosts protein production, promotes the utilization of fat, interferes with the action of insulin, and raises blood sugar levels. GH also raises levels of insulin-like growth factor-1 (IGF-1).
GH is available as a prescription drug that is administered by injection. GH is indicated for children with GH deficiency and others with very short stature. It is also approved to treat adult GH deficiency — a condition that almost always develops in conjunction with major problems afflicting the hypothalamus, pituitary gland, or both. The diagnosis of adult GH deficiency depends on special tests that stimulate GH production.
Adults with bona fide GH deficiencies benefit from GH injections. They enjoy protection from fractures, increased muscle mass, improved exercise capacity and energy, and a reduced risk of future heart disease. Specifically with HGH Therapy, 30% of patients experience side effects that include fluid retention, joint and muscle pain, carpal tunnel syndrome (pressure on the nerve in the wrist causing hand pain and numbness), and high blood sugar levels.
Human Growth Hormone, also known as hGH, has been utilized in recent years as a therapy for anti-aging. This particular growth hormone, produced by recombinant gene technology, is given to help restore youthful vitality making patients feel and look younger. Even though Human Growth Hormone has been proven effective for the aging patient, there is another option. HGH Semorelin Therapy.
Sermorelin GH Therapy
Sermorelin is a form of Growth Releasing Factor (GRF). Sermorelin is a small peptide containing only 29 amino acids while hGH, on the other hand, is a large molecule containing 191 amino acids. However, studies have shown that it is only the first 29 amino acids out of the full 44 amino acids in GRF that stimulate pituitary secretion of human growth hormone. Therefore, the chemical name of Sermorelin is GRH 1-29. Sermorelin is currently the only product currently available that has the ability to enhance the effects of hGH.
Sermorelin vs HGH
In HGH Therapy, the main difference is Sermorelin is a secretagogue. This means, it is not growth hormone itself, but it actually stimulates the pituitary gland to produce more growth hormone naturally. This gives the body the benefits of hGH without giving the actual hormone. This bypass of injected hGH prevents many problems.
Unlike Sermorelin, when you use HGH injections, it accumulates in the body. Levels of exogenous hormone increase for a while and then drop back down suddenly. Patients taking HGH often experience benefits for a period of time and then the effects abruptly stop. It then takes more and more medication to produce the same original effect, and taking too much can lead to severe HGH side effects.
Because Sermorelin stimulates growth hormone production naturally, it is typically much safer than HGH. With Sermorelin, the body attempts to self regulate how much or how high hormone levels can get. This type of regulation is referred to as normal feedback; a protection mechanism of the body. When levels, get too high, normal feedback mechanisms help bring levels to a more safe and steady state. This regulation of the body prevents the “square wave” pattern seen with HGH, thus preventing sudden drops of hormone levels.
There are over the counter secretagogues that are said to increase HGH levels much like Sermorelin. These products such as L-glutamine, L-dopa, L-arganine, L-orirnithine, glycine, ornithine alpha-ketoglutarate and herbs such as Macuna pruriens and Tribulus terrestris are amino acids that, in high doses, may elicit a small release of HGH from the pituitary. However, their effect is non-specific and typically intermittent and unreliable because they do not work on any specific receptor on the pituitary gland. High doses of amino acids can also produce kidney problems. Because Sermorelin’s action mimics the body’s naturally occurring growth hormone releasing process, this is not an issue.
The only method of administration currently available for Sermorelin is by subcutaneous injection. Even though HGH and Sermorelin work at different places in the body (Sermorelin at the pituitary and HGH at the liver), the dosages are comparable. Typically, Sermorelin is prescribed in micrograms and HGH in international units (IU). Sermorelin cost is also much lower than HGH.
The timing of the daily Sermorelin injection is also important. Sermorelin is given once a day at bedtime. Timing the injection prior to sleep is important because Sermorelin complements the body’s natural production and release of Growth Releasing Factor during sleep.
In the battle of Sermorelin vs HGH, it is clear using Sermorelin in place of HGH has numerous benefits. It not only is cost effective and easier to obtain, but it is more importantly a safer option for increased growth hormone production within the body without the side effects.
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